United beat the Bundesliga side 4-2 in September, with Ferdinand recalling "there was a lot of fluidity about our team – good interchanges, quick passing, plenty of first-time balls and lots of running".
"It was good but we want to improve further on that," he said. "We need to pick up points and it would be nice if we could finish the job this week with a win."
Victory would secure safe passage to the competition's latter stages and Rio and his team-mates are eyeing qualification with a game to spare.
"If we go there and put in a good team performance I'm sure we can come away with the points," he said.
Leverkusen warmed up for Wednesday's clash with a 1-0 win against Hertha Berlin, with striker Stefan Kiessling scoring his 12th goal of the season so far.
Kiessling didn't net when United and Bayer met earlier this season, but Ferdinand knows exactly what the 29-year-old is capable of.
"He has good movement and we watched a lot of videos on him before [the game at Old Trafford] so we knew a lot of the dangers he posed. He's scored a lot of goals over in Germany