The hosts couldn't cope as the Reds romped into a 3-0 lead after 22 minutes with goals from Antonio Valencia, Robin van Persie and Wayne Rooney.
The scoring began in the ninth minute thanks to some excellent build-up play. Van Persie produced an excellent turn and threaded pass to put Rooney clear and although the latter could have fired towards goal, he opted to wait and set up Valencia to side-foot home.
After former United striker Dimitar Berbatov had nearly got in behind the Reds’ defence, almost immediately David Moyes’ men went up the other end to double the advantage on 20 minutes. Adnan Januzaj dispossessed Scott Parker in midfield before putting van Persie through to smash into the roof of the net. Two minutes later van Persie turned provider. An excellent Tom Cleverley pass sent the striker free down the right and he advanced into the area before sending an inch-perfect cross to Rooney who couldn’t miss.
After injuries had forced Moyes into making a triple substitution at the break – Marouane Fellaini, Shinji Kagawa and Chris Smalling replaced Cleverley, Rafael and Jonny Evans – Fulham gave themselves a lifeline on 65 minutes when substitute Alexander Kacaniklic's effort was deflected past David De Gea by Rooney’s outstretched boot. Although Darren Bent headed on to bar late on, the Reds deservedly came away with three points.