Nani and Portugal's only hope of automatic qualification is Group F leaders Russia losing to Azerbaijan, while the Portuguese must beat Luxembourg heavily enough to overtake the Russians on goal difference.
In the same group, Northern Ireland's miserable campaign will end in Israel minus United's Jonny Evans, suspended following his red card in the defeat to Azerbaijan last week.
Belgium booked their place in next summer's tournament when they beat Croatia last Friday, but Marouane Fellaini will sit out his country's meeting with Wales having picked up a yellow card in last week's outing.
Javier Hernandez's Mexico can still qualify automatically but they must beat Costa Rica and hope that third-placed Honduras lose to Jamaica, while improving their goal difference ahead of the Hondurans.
Ecuador, featuring Antonio Valencia, will grab one of the two remaining automatic qualification spots for South American teams if they draw with Chile, who would also head to Brazil next year with that result. United striker Angelo Henriquez, on loan
CHILE v Ecuador - Angelo Henriquez
Chile v ECUADOR - Antonio Valencia
ENGLAND v Poland - Michael Carrick, Phil Jones, Wayne Rooney, Chris Smalling, Danny Welbeck
FRANCE v Finland - Patrice Evra
Belarus v JAPAN - Shinji Kagawa
Costa Rica v MEXICO - Javier Hernandez
Turkey v NETHERLANDS - Robin van Persie
PORTUGAL v Luxembourg - Nani