David Moyes is hopeful that United's international contingent will be in contention for the visit of Southampton to Old Trafford on Saturday.
A host of Reds were in action for their countries in the latest round of World Cup qualifiers and friendlies, which concluded on Tuesday.
No major injury concerns have been reported since the United squad reconvened at the Aon Training Complex ahead of the champions' return to action in the Barclays Premier League, but some slight knocks picked up over the two weeks since the win over Sunderland will be assessed.
"Sometimes you get the international break on the back of a bad result and sometimes off a good result. We went into it with a good result," said the boss. "It's always a concern, especially when you have so many players away like we do. I'll monitor training, one or two are nursing knocks so we'll need to look at it but hopefully they will be okay."
The manager also paid tribute to the part United's players had in ensuring that Roy Hodgson's England qualified automatically for next year's World Cup in Brazil.
"We have a lot of England internationals who play for Manchester United and that's pleasing as I'm sure it's a big boost for them and a big boost for the country as well. It's a great achievement for Roy and the team to get to the finals and I congratulate him on that.