David Moyes' side entertain Newcastle and travel to Hull City in early kick-offs while the home clash against Tottenham has been switched to a 5.30pm start on New Year's Day.
The champions' visit to Aston Villa has been moved back to Sunday 15 December with a 1.30pm kick-off.
All times are GMT as the Reds will aim to end 2013 in style and begin 2014 with a win against Spurs at Old Trafford to erase memories of the 4-1 defeat to the North Londoners at White Hart Lane on the same day in 1996.
Manchester United v Newcastle United, Saturday 7 December KO 12.45pm live on BT Sport
Aston Villa v Manchester United, (originally Saturday 14 December) Sunday 15 December KO 1.30pm live on Sky Sports
Hull City v Manchester United, Thursday 26 December KO 12.45pm live on Sky Sports
Manchester United v Tottenham Hotspur, Wednesday 1 January KO 5.30pm live on BT Sport