The evergreen midfielder came off the bench to replace Marouane Fellaini and has now played in more games at the elite European level, including qualifiers, than legendary Spanish striker Raul.
"It means a lot," he told MUTV. "It’s the pinnacle of European football and to play that many games is obviously special."
Giggs was a little disappointed that the Reds could not retain the lead secured through Danny Welbeck's first-half strike.
"When you’re playing for United and you go 1-0 ahead, you expect to be able to see the game out," he admitted. "But fair play to Shakhtar - they’ve got some decent players and they put us under a lot of pressure. We’ve won our first game and drew a very tough away game so we’ll take that.
"We are in a good position; it’s a tough place to come this. Hopefully we can get a few victories from the next couple of games and
145 Ryan Giggs
140 Paolo Maldini
131 Clarence Seedorf
130 Paul Scholes
129 Iker Casillas*
* still playing in Europe