United begin the new UEFA Youth League with a fixture against Bayer Leverkusen at Salford City Stadium on 17 September.
Nicky Butt is to take charge of an Under-19 squad for a competition that mirrors the Champions League at the group stages. The opening game will kick off at 4pm BST ahead of the senior clash at Old Trafford later that evening.
Two of the three away clashes in Group A have still to be confirmed but the final home match of the opening stages, against Ukrainians Shakhtar Donetsk, will be held at Leigh Sports Village.
The knockout rounds are all single matches rather than two legs with the draw taking place on 13 December. There is no extra time with the ties going straight to penalties if level after 90 minutes.
The final will take place in Nyon on Monday 14 April to decide the winners of the Lennart Johansson Trophy, which is named after UEFA's honorary president.
17/9/13: Bayer Leverkusen (H)
16.00 BST, Salford City Stadium
2/10/13: Shakhtar Donetsk (A)
13.00 BST, Olimpiyskiy Stadium
23/10/13: Real Sociedad (H)
14.00 BST, Salford City Stadium
TBC: Real Sociedad (A)
TBC, Zubleta Training Ground
TBC: Bayer Leverkusen (A)
TBC, Ulrich-Haberland Stadium
9/12/13: Shakhtar Donetsk (H)
19:00 GMT, Leigh Sports Village