The striker reached the milestone with a cool finish past visiting goalkeeper Bernd Leno after he had earlier put the Reds in front with an assured side-footed volley from close range.
Only four other men in history have hit the 200 milestone: Sir Bobby Charlton (249 goals), Denis Law (237) and Jack Rowley (211).
It's taken Rooney just 406 appearances to bag his double century, meaning he scores, on average, almost a goal every other game. At just 27 years of age, the club's all-time record must surely be in the striker's sights.
"To surpass Sir Bobby would really be something," David Moyes admitted afterwards.
Rooney's goals on Tuesday also took him to second in United's Champions League scorers chart, past Ryan Giggs. He now has 30 goals, just eight shy of Ruud van Nistelrooy's record tally.
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