Perhaps most notably, striker Wayne Rooney scored twice to take his personal tally for the club to 200. He joins Jack Rowley, Denis Law and Sir Bobby Charlton in the short list of Reds who have reached the milestone.
Of course, new manager David Moyes also took charge of his first group stage game in the competition, having previously contested an unsuccessful qualifying tie with previous club Everton.
Transfer deadline day signing Marouane Fellaini even took his European bow for the club, producing a steady performance in the heart of midfield before exiting with cramp on 81 minutes.
As ever, to help retell the story of the game, we’ve compiled the best photographs taken by official club snappers John and Matt Peters, which you can view in the gallery above.