Reserves coach Warren Joyce was unable to risk Wilson in the Under-21s' 2-1 victory over West Ham at Old Trafford due to illness while Pereira, who hit an excellent winner, was replaced with a knock on Monday night.
The duo, who have scored all the team's goals between them during the cup run for Paul McGuinness' Under-18s, have a good chance of featuring in the clash at the John Smith's Stadium, which will be screened live on MUTV.
"Wilson was ill which was unfortunate as, last week [against Leicester City], I thought he was outstanding," Joyce told MUTV. "We had no other strikers left really within the club as we have got a lot of players out on loan, who need to be out on loan and playing at that level. It was to leave space for Wilson but obviously there is an important FA Youth Cup game coming up on Friday, and we thought maybe it was too soon for him.
"He might not do himself justice and be struggling for Friday but now, at least, he is going to be right for that one.
"It was just a little kick for Pereira at the end so we took him off as a precaution as well with Friday in mind. He has done well in the last few weeks and it was an outstanding goal in the first half. I told him he needed that because he cost us goal for not tracking the full-back! So it was a good lesson for him as it was the first thing I mentioned at half time!"
Wilson's absence led to Pereira and Jesse Lingard sharing the central striking duties without a recognised centre-forward available to Joyce for the win against the Hammers.