The Manchester United winger knows another Honduran, Maynor Figueroa, from their time playing together for Wigan under Steve Bruce but he said their friendship will go out of the window after both nations lost their opening fixtures in Group E.
"I feel sorry for Wilson getting sent off," said Valencia. "I hope he recovers quickly emotionally from this [bad] moment. But we have to give everything for the country. We have a positive frame of mind."
A decade after making his international debut, also against Honduras, there is increased responsibility on Valencia as Ecuador captain and he will be asked to make a major contribution on his 72nd appearance for his country.
His national coach Reinaldo Rueda declared "Tono is okay" after the player received some criticism for his performance against Switzerland and declared any pressure on Valencia is normal and something that has been constant over the years.
Victory is the target for Ecuador and Honduras, with Switzerland and Patrice Evra's France billed as favourites to progress to the knockout stages.