When the teams last faced off back in December, Welbeck scored as the Reds swept to a comfortable 3-1 win at Old Trafford. However, a pair of 2-2 draws at Upton Park last season, in the league and the FA Cup, highlight how hard it can be to beat Sam Allardyce's Hammers in their own backyard.
"It's a difficult place to go," Welbeck told MUTV. "They have their own style of football which is difficult to play against, you have to be prepared to put a physical challenge up against them. We also have to be mentally right in order to get the three points."
When asked whether Wednesday's 3-0 win over Olympiacos could be the perfect springboard for the weekend, Danny was keen not to place too much emphasis on the confidence gained. The striker stressed that self-belief should be a given at United.
"We've got to be confident all the time, we can't just look back at one game and say this is it," the England international added. "We have to look to the future and the next game in particular which is always the most important. You can’t start looking too far in front. We just have to be confident going into the next game and we'll start at West Ham."