Two youngsters who have risen through the Reds' ranks - Michael Keane and Jesse Lingard - are in Southgate's squad for the European Championship qualifier against Wales on Monday evening. Unfortunately their long-term team-mate Sam Johnstone has had to withdraw through injury, as has Wilfried Zaha, Sir Alex Ferguson's last-ever signing for United.
In a recent interview with ManUtd.com, Southgate backed the ethos at the Aon Training Complex to produce rounded individuals and professionals capable of forging a career - either with United or elsewhere.
"I think the United character is important," he explained. "We have a duty when developing young players to develop people as well. Through coaches like Paul McGuinness, Warren Joyce and Brian McClair at United, I know they have good habits when they come and there are never any problems with them. They come to learn, train hard and obviously they have good quality as well. That makes life for us a lot easier when the boys come through the door like that.
"I think that’s one of the great things about United over the years - it’s not just the players who have got into their own first team but, when I go and see a team like Leicester City play, two or three of the lads have grown up at United through their system. They have developed boys who have had successful careers in the game at one level or another, and that’s important."