Whatever happens on Wednesday, it’s unlikely to go quite the same way as United’s last December encounter at Fulham.
Two years ago this week, an injury-ravaged side featuring Michael Carrick and Darren Fletcher as makeshift defenders went down 3-0 in west London on an afternoon to forget.
Sir Alex will be taking a decidedly stronger squad to Craven Cottage this time, with the Reds’ current injury situation looking brighter after the weekend win two miles away at QPR.
And while Carrick’s primary function is still to screen the back four, he’s not expecting to be called upon as an out-and-out defender again any time soon.
The in-form midfielder told ManUtd.com: "I remember the game two years ago, though not that well!
"It was just one of those situations: we had no defenders left so me and Fletch played at centre-half.
"I’d played there for two or three matches before that and we’d won, but that was probably one game too many. It wasn’t a great day for us."
"We know Fulham are a strong team: they’re well organised and Craven Cottage is a tough place to visit, but it’s a good, old-fashioned football ground and we look forward to going there."
– Michael Carrick
United's Premier League record at Fulham:
Last visit: Fulham 2-2 United, 22/08/2010