The Reds take on Dutch outfit Ajax for only the second time ever in European competition on Thursday, in the Round of 32 first leg.
United's only win on the road in Europe so far this season came in October against Romanian minnows Otelul Galati, during the disappointing Champions League campaign.
And with Sir Alex already confirming he’ll field his strongest team at the Amsterdam ArenA, United are out to secure a commanding position ahead of next week's Old Trafford return.
"Playing at home in the second leg is important but it’s only a small advantage – it doesn’t guarantee victory," Hernandez told MUTV.
"It’ll be a difficult game but we’ll go to Amsterdam looking to win.
"The Champions League is the best competition in Europe and it’s a bit strange to be in the Europa League. But we want to win every tournament we enter.
"Both teams have a lot of history in Europe, so it should be a great game."