There will be one last opportunity for fans to admire the midfielder's radar-like passing and hopefully see a trademark piledriver explode into the net.
Eric Cantona will be with his Cosmos team but even the appearance of the United idol will fail to take away from the fact that the evening is dedicated to shy Scholes, despite the new Reds coach's wishes on that front.
The Americans are bringing a 19-man squad that includes former Reds Gary Neville, Nicky Butt and Dwight Yorke. Premier League performers such as Brad Friedel, Robbie Keane and Michel Salgado also feature, along with ex-Arsenal duo Sol Campbell and Patrick Vieira. Italy's retired World Cup-winning captain Fabio Cannavaro will bring a touch of glamour to the defence.
Eight of Cosmos' Under-23 players get their chance to play at the Theatre of Dreams in front of the sell-out audience while Sir Alex has a full squad to choose from, apart from Javier Hernandez, who is being eased back after concussion.
United (from): De Gea, Kuszczak, Lindegaard, Amos; Evra, Jones, Ferdinand, Smalling, Vidic, Fabio, Rafael, Evans; Anderson, Giggs, Park, Carrick, Nani, Scholes, Young, Fletcher, Valencia, Obertan, Gibson, Cleverley, Pogba, Norwood, Morrison; Owen, Berbatov, Rooney, Welbeck, Macheda, Diouf.
Cosmos (from): Friedel, Calderone; Neville, Bridge, Cannavaro, Campbell, Salgado, Reyering, Murphy; Vieira, Pires, Butt, Diaby, Iraheta, Gaitan; Yorke, Keane, Dimitrov, McBride.