Manucho could make his first start of the season on Thursday evening, having been named in the Reserves' squad to face Wigan Athletic.
The Angolan international has made just one fleeting substitute appearance for the Reds' senior side since joining in January, but looks likely to start against the Latics.
Ole Gunnar Solskjaer has seen his side deprived of the Da Silva twins, Rodrigo Possebon and Danny Drinkwater through injury, but the Norwegian and Warren Joyce have still put together a side full of attacking talent.
Manucho joins Federico Macheda and Anton Bryan as the Reds' striking options, while a combination of Tom Cleverley, Sam Hewson, Darron Gibson, Cameron Stewart and Magnus Eikrem will fill the midfield berths.
Ben Amos' promotion to senior duties, together with a host of goalkeeping injuries throughout the Carrington ranks, means either Gary Woods or Conor Devlin will make their Reserves debut in goal.
As ever, the match will be shown live on MUTV, with coverage starting at 18:30 ahead of the 19:00 kick-off.
United squad: Woods, Devlin; Gray, Eckersley, C Evans, Chester, Derbyshire, Gill; Gibson, Eikrem, Hewson, Cleverley, Stewart; Manucho, Macheda, Bryan.