United's Reserves will contest three Manchester Senior Cup fixtures before starting the new Barclays Premier Reserve League season.
Ole Gunnar Solskjaer and Warren Joyce's side will face Manchester City, Oldham Athletic and Stockport County before opening the league campaign against Aston Villa.
A Lancashire Senior Cup first round tie at Bury is then followed by another MSC clash, this time with Bolton, as the cup competitions dominate United's early season schedule.
The Reds' two final MSC group games come in early 2011, against Bury and Rochdale. Click here for a full, updated Reserves fixture list.