Alexander Büttner is set for a run-out at Under-21 level as United look for a victory at Aston Villa that should ensure qualification for the elite phase of the competition.
Anything less than three points in the final group game will be insufficient but the Dutch left-back's inclusion as an over-aged player should provide some additional experience while Scott Wootton and Nick Powell also feature after starting in the last Champions League tie against CFR Cluj.
Italians Davide Petrucci and top scorer Federico Macheda are likely to be key figures as the Reds bid to avenge a 1-0 home reverse to the Villans.
The match is exclusively live on MUTV with kick-off at 7pm.
Squad: Jonny Sutherland, Pierluigi Gollini; Marnick Vermijl, Tom Thorpe, Scott Wootton, Michele Fornasier, Alexander Buttner, Sean McGinty, Frederic Veseli; Larnell Cole, Ryan Tunnicliffe, Davide Petrucci, Nick Powell; Federico Macheda, Bebe, Tom Lawrence.