The Reds make the short trip to the Etihad Stadium and, while the circumstances could be better, it does provide Warren Joyce's successul side with another chance to grab some silverware.
After winning the Barclays Premier Reserve League play-off against Aston Villa on penalties at Old Trafford last week, there is the opportunity for more glory in the Blues' backyard.
All the players are looking forward to the encounter and will be out for revenge after being beaten 4-2 at home by City in February earlier in the competition. "It's turned into a very big game," admitted Joyce to MUTV, acknowledging how the clubs' senior title race panned out.
City's 'Elite Development Squad' will have plenty of selection options while Joyce has confirmed he'll stick with the players who won the title which means many of those on duty against Villa are set to feature again. Larnell Cole looks set to miss out through injury but Paul Pogba is back to take his place in the squad while Michele Fornasier and Luke Giverin are involved despite taking part in Harry Gregg's Testimonial in Belfast on Tuesday.
United squad: Ben Amos, Sam Johnstone; Marnick Vermijl, Michele Fornasier, Reece Brown, Scott Wotton, Michael Keane, Ezekiel Fryers, Luke Giverin; Paul Pogba, Ryan Tunnicliffe, Tom Thorpe, Davide Petrucci, Jesse Lingard, Robbie Brady; Will Keane.
City squad: Eirik Johansen, Reece Wabara, Shay Facey, Karim Rekik, Jeremy Helan, Emyr Huws, Abdul RazaOmar Elabdellaoui, Gai Assulin, Denis Suarez, Luca Scapuzzi, Tom Halsall, Sean Tse, Fillipo Mancini, Jordi Hiwula, Albert Rusnak, Courtney