The Reserves will play at both Old Trafford and the Etihad Stadium in the space of seven days in May, with silverware up for grabs on both occasions.
Warren Joyce's men, already champions of the Barclays Premier Reserve League North, will welcome southern winners Aston Villa to Old Trafford on Thursday 10 May (19:00 BST) for the national play-off final, a week before meeting Manchester City at the Etihad Stadium in the Manchester Senior Cup final.
Ticket details for both finals will be announced soon.
Before that, the Reds' second-string have an opportunity to progress to the Lancashire Senior Cup final by beating Blackpool at Moss Lane, Altrincham, on Tuesday 1 May (19:00).
Meanwhile, the league game against Sunderland, previously scheduled for that evening, will now be played on Friday 4 May (also at Altrincham, 19:00).