United will look to close the gap at the top of the Barclays Under-21 Premier League table with a home fixture against Stoke City on Monday night.
Warren Joyce's side know only an unrealistic avalanche of goals will usurp Tottenham at the summit following Spurs' impressive run of form, that included a 4-2 win in the Reds' last league outing, but victory at Moss Lane would match the Londoners' tally of 14 points, with a game still in hand.
Stoke are currently at the foot of National Group 2, six points adrift, and were beaten 1-0 by United on the opening weekend of the campaign.
As per the teamsheet, the United line-up is: Johnstone; Vermijl, Wootton, Fornasier, McGinty; Cole, Thorpe, Tunnicliffe, Powell, Januzaj; Macheda. Subs: Veseli, Sutherland, Lawrence, James, Ekangamene.
The match is live on MUTV with kick-off at 19:00 BST.