Warren Joyce's side know only an unrealistic avalanche of goals will usurp Tottenham at the summit following Spurs' impressive run of form, that included a 4-2 win in the Reds' last league outing, but victory at Moss Lane would match the Londoners' tally of 14 points, with a game still in hand.
Stoke are currently at the foot of National Group 2, six points adrift, and were beaten 1-0 by United on the opening weekend of the campaign.
As per the teamsheet, the United line-up is: Johnstone; Vermijl, Wootton, Fornasier, McGinty; Cole, Thorpe, Tunnicliffe, Powell, Januzaj; Macheda. Subs: Veseli, Sutherland, Lawrence, James, Ekangamene.
The match is live on MUTV with kick-off at 19:00 BST.