Warren Joyce's side are in third place in the table after a last win in the competition came four games ago against the Magpies, 4-2 at Moss Lane. Nonetheless, with only one defeat all campaign, the Reds could go above both the Tynesiders and leaders Tottenham with a victory, although Spurs are also in action against Southampton.
Keeper Johnstone and Nick Powell are in the England Under-21 squad to face Northern Ireland in Blackpool on Tuesday while Joshua King is sidelined with the injury that forced him to withdraw from international duty with Norway.
Robbie Brady, Michael Keane, Jesse Lingard and Sean McGinty have all departed the club on loan.
United (from): Jonny Sutherland; Frederic Veseli, Scott Wootton, Michele Fornasier, Marnick Vermijl; Bebe, Tom Thorpe, Ryan Tunnicliffe, Adnan Januzaj, Larnell Cole; Federico Macheda; Tom Lawrence, Reece James, Kieran O'Hara, Charni Ekangamene, Luke Hendrie, Luke McCullough.
The action is exclusively live on MUTV.