The Reds have bad memories of the last visit to the Eppleton Colliery Welfare ground as the Reserves suffered a 6-3 defeat in terrible conditions. This time around, Warren Joyce's top-of-the-table team will look to continue a flawless start to the league campaign.
"Last year's match at Sunderland was a shambles," Joyce told MUTV. "I wouldn't call it a goalfest. Some of the goals that went in were very poor.
"Newcastle was a good educational game and one to talk about. Last week, we talked about standards improving and getting better. People were desperate to play in the Capital One Cup but they have no divine right to play in it.
"It's got to be hard to play for Manchester United. I talked about people like Tom Cleverley, who made his debut for United in the cup and the journey he's been on for years of working hard and continuing to work hard to try and improve. That's a lesson for all these lads. It's just about retaining that hunger and desire to get better every single day not every game. You have got to improve every single day."
With Ryan Tunnicliffe and Jesse Lingard called up to the senior squad for the Champions League tie with CFR Cluj, changes will need to be made to the XI on duty at Moss Lane last week.
Larnell Cole could move forward from right-back with Marnick Vermijl recalled. Italian pair Davide Petrucci and Federico Macheda, who has four goals in three league games this term, are again likely to be key figures. Meanwhile Angelo Henriquez could feature in his first away match after