Manchester United's Under-21s will face Tottenham at the Salford City Stadium on Monday 15 April.
The game has been switched from the regular home location of Altrincham's Moss Lane and entry will be free for all spectators. Spurs are currently top of the table with United also in strong contention to qualify for the semi-finals of the Barclays Under-21 Premier League as one of the three top sides in the division.
Kick-off is at 7pm at the new stadium, which is home to Salford City Reds and Sale Sharks and is based in Eccles.
Joyce's youngsters also have games at Old Trafford against Liverpool (19 April) and West Brom (30 April) to look forward to. Tickets are priced £5 for adults and £2 for concessions but entry is free to season-ticket holders and members. Call the Ticket Office on 0161 868 8300.
Meanwhile, the Lancashire Senior Cup tie with Oldham will be played behind closed doors at Carrington on Friday 3 May at midday.