More silverware is up for grabs for Warren Joyce's perennial trophy winners with this competition traditionally held over from last season, when the Reds qualified with a victory against Oldham back in May.
Joyce's team won last term's inaugural Barclays Under-21 Premier League and also the Manchester Senior Cup with the players picking up their medals over the summer.
City provide the opposition for what promises to be a keenly-contested affair, evoking memories of the win in the Manchester Senior Cup final in 2012 at the Etihad Stadium when Will Keane and Luke Giverin scored in a 2-0 success.
"Obviously, it’s a local derby again and it’s good to play City in the final," Joyce told ManUtd.com. "I’m sure it will be a good, competitive game. It’s great for the lads - either you can say we won two or three cups depending on the calendar.
"The team won everything they could last year so we’ve either got to carry over and got to win this Lancashire Senior Cup or, technically, we played in the Lancashire Senior Cup final last year so we’ve won all three."
Midfielder Charni Ekangamene is also eagerly anticipating the chance to take on City with a trophy at stake.
"We have to step up now and get ready for the big test against them," the Belgian explained. "Hopefully, we’ll get the cup. It was a good win at the end of the 2012 season at their ground. It’s always a great feeling if you can beat your neighbours."