Vermijl adapting to a holding midfield role after Tyler Blackett replaced the injured Charni Ekangamene.
There was a hopeful handball appeal against Lloyd Jones when he got in the way of a left-footed strike by Lingard while Tom Lawrence was the second introduction from the bench when Angelo Henriquez was withdrawn.
Borini had the ball in the net again but was flagged offside although most of the pressure came from the Reds with Januzaj a constant menace with his bewitching dribbling skills. However, there were few clear-cut chances of note despite the pressure, with Cole failing to keep one long-range attempt down.
The pass of the match by Keane released Januzaj for another run that carved out a near-post opportunity for Lawrence, who could only head wide. And there was no way back once Borini latched onto an underhit backpass to score from an acute angle and claim his second of the night.
Fittingly, Januzaj had one last noteworthy effort with a deflected curler that had Dan Ward sprawling but dropped off target. The result may have been disappointing but there was plenty to admire on the night at the new regular home venue.
United: Amos; Varela, Thorpe, M.Keane, Vermijl; Cole, Ekangamene (Blackett HT), Petrucci, Lingard; Januzaj; Henriquez (Lawrence 59). Subs not used: Gollini, Rothwell, Grimshaw.