Warren Joyce's side look to maintain a winning start to the Barclays Under-21 Premier League Elite Group when Arsenal visit Moss Lane on Monday night.
The Reds hammered Oldham 7-0 in the Manchester Senior Cup last week with Larnell Cole grabbing four of the goals as plenty of players staked their claim to keep a place in the team at league level.
Frederic Veseli and Adnan Januzaj were others to impress but John Cofie is likely to be absent after scoring for his new club Notts County at the weekend. Although, due to the terms of the youth loan, he can still represent the Reds, the striker admitted he was tired after his exertions on Saturday.
With Angelo Henriquez, Bebe and Federico Macheda also out on loan, and Will Keane yet to make his return from injury, there is an obvious question mark over who will lead the attack as coach Joyce ponders his options.
The match is live on MUTV with another fixture, against the Gunners' North London neighbours Tottenham, due to take place on Friday afternoon.