The fixture is taking place at Leigh Sports Village and will give an opportunity for the players not on tour to promote their claims.
A number of those involved are expected to feature at Under-21 level next term while Scott Wootton and Davide Petrucci are fit again after injuries interrupted their loan spell at Peterborough United. Bebe and Federico Macheda also back from their loans, with Rio Ave and Stuttgart respectively.
Sam Johnstone, Tom Thorpe and Larnell Cole are available following their Under-20 World Cup exertions with England.
United squad: Sam Johnstone, Pierluigi Gollini; Liam Grimshaw, Scott Wootton, Marnick Vermijl, Louis Rowley, Tom Thorpe; Charni Ekangamene, Davide Petrucci, Ben Pearson, Andreas Pereira, Larnell Cole, Ryan Tunnicliffe; Bebe, Tom Lawrence, Federico Macheda, Jack Barmby.