Ryan Tunnicliffe returns to the fold after his loan spell at Barnsley while no out-and-out striker is selected with Adnan Januzaj and Jesse Lingard being asked to provide the chief goal threat.
Warren Joyce's side have kept five clean sheets in a row and boosted the chances of reaching the semi-finals of the competition with a fine 2-0 success at West Brom on Sunday. The squad has already travelled south for the testing encounter against Arsenal at Barnet's Underhill.
Nick Powell is with the England Under-19s ahead of their game on Thursday with Turkey while Tom Lawrence is another player who received an international call-up (with Wales Under-21s). Sam Johnstone is unavailable after joining Walsall on loan with Pierluigi Gollini getting the nod in goal.
The two teams contested an entertaining 2-2 draw in the corresponding game at Moss Lane and another exciting clash is anticipated.
The match, which kicks off at 19:00 GMT, is exclusively live on MUTV.
United: Gollini; Vermijl, Thorpe, McGinty, Buttner; Cole, Veseli, Tunnicliffe, Ekangamene, Lingard; Januzaj. Subs: Blackett, Sutherland, Cofie, Fornasier, Daehli.