Warren Joyce's side have only played twice in the new division thus far, losing to Liverpool and winning at West Brom.
With Tuesday's UEFA Youth League encounter against Bayer Leverkusen to consider, there may be a smaller pool of players available and loan moves will also deprive the Reds of the services of the likes of Davide Petrucci, Marnick Vermijl and Bebe plus two of the scorers at The Hawthorns in Angelo Henriquez and Nick Powell.
Executive Club members, season-ticket holders and official members can gain free entry to Under-21 fixtures by texting UNDER21 and their Membership number to 60777 (production of the membership card will be required at the gate.)
All other supporters can purchase a ticket for £3 from Salford City Stadium's ticket office. Entry is free for Under 16s, and free parking is also available.
The Trotters also provide the opposition in the Manchester Senior Cup at the end of the month.