The Barclays Under-21 Premier League clash is a first run-out at the Theatre of Dreams this term for Joyce's squad. The fact there has only been one FA Youth Cup tie at the stadium in the past two seasons also means there will be little experience of the venue for a number of the players.
"We don't play enough on the main ground," admitted Joyce. "It will be a good experience for them and hopefully we will get a bit of a crowd in for this one. I'm sure we will put on a performance for anybody who wants to come and watch."
Jesse Lingard could be a key figure against the Hammers as he is the Reds' top scorer in the Under-21 league with five goals. Indeed, following Larnell Cole's exit to Fulham, he is the only member of the squad to have netted more than once in the division this term.
"All Jesse can do is impress more and wait for his chance," explained Joyce. "Then he has got to take it. He has just got to keep doing more every day and in every game he plays. He has to try to make that opportunity open up for himself. That is all any young player can do."
Last time out, United's Under-21s returned to winning ways with a 1-0 away triumph against Leicester City, thanks to a free-kick by Davide Petrucci. Another victory at Old Trafford on Monday would take the Reds above fifth-placed West Ham in the table and increase the prospect of a top-four spot and a place in the semi-finals of the competition.
Entry to the match is free for executive club members, season-ticket holders, members and