Manchester United Under-21s face Leicester City on Monday night with the game switched from the King Power Stadium to the Ricoh Arena in Coventry.
With ten players embarking on new loan spells over the weekend, Warren Joyce will have a different look to his side and must cope without defensive linchpin and captain Tom Thorpe. Michael Keane's return from a stint at Derby County means he looks a ready-made replacement at the heart of the back four.
Will Keane's temporary departure to QPR could ensure a place in attack for James Wilson, if he has recovered from the ankle injury that has ruled him out recently. Under-21 regulars Larnell Cole and Charni Ekangamene are also missing, with the former joining Fulham on a permanent basis and the latter being loaned to Carlisle, and there will be a change in goal after Sam Johnstone moved to Doncaster Rovers for a month.
There is likely to be a more youthful look to the line-up with Andreas Pereira and Ben Pearson among the possible options to start. The Barclays Under-21 Premier League clash is live on MUTV with coverage starting at 18:30 GMT.