With ten players embarking on new loan spells over the weekend, Warren Joyce will have a different look to his side and must cope without defensive linchpin and captain Tom Thorpe. Michael Keane's return from a stint at Derby County means he looks a ready-made replacement at the heart of the back four.
Will Keane's temporary departure to QPR could ensure a place in attack for James Wilson, if he has recovered from the ankle injury that has ruled him out recently. Under-21 regulars Larnell Cole and Charni Ekangamene are also missing, with the former joining Fulham on a permanent basis and the latter being loaned to Carlisle, and there will be a change in goal after Sam Johnstone moved to Doncaster Rovers for a month.
There is likely to be a more youthful look to the line-up with Andreas Pereira and Ben Pearson among the possible options to start. The Barclays Under-21 Premier League clash is live on MUTV with coverage starting at 18:30 GMT.