Continuing to hold the upper hand, the Reds looked for more goals but Southampton remained in the game as it entered the closing stages. Indeed, they went close with Harrison Reed dragging a shot wide at the near post.
Yet United held out with some resolute defending as Tom Thorpe made some well-timed interceptions and clearances.
United: Johnstone; Love, Blackett, Thorpe, James; Cole, Ekangamene, Petrucci, Lingard; W.Keane (Rothwell 88), Macheda. Subs not used: Gollini, Pearson, Grimshaw, Weir.