The league fixture has been moved from AFC Telford's Watling Street ground to Molineux and the MUTV cameras will be at the famous old stadium to provide live coverage.
Michael Keane and Jesse Lingard have both departed on loan, to Blackburn Rovers and Brighton & Hove Albion respectively, and their experience and quality will be missed. However, Warren Joyce has been keen to blood younger players and the signs have been positive from those included in recent weeks.
Tyler Blackett started against Sunderland despite his loan at Birmingham and could be an option in the middle, as could Charni Ekangamene who is at Carlisle, with United short on natural central defenders. Blackett came on as a substitute in the Under-21 season opener against Liverpool and only three of those who played that night in August are available for selection.
Full-back Guillermo Varela (pictured), midfielder Davide Petrucci and goalkeeper Ben Amos are the trio in question, with Adnan Januzaj long since promoted to the first-team squad. United are currently seventh in the 22-team table while Wolves remain in the bottom three despite a 1-0 win at local rivals West Brom.