Will Keane and Ravel Morrison were on target for United's Under-18s as the young Reds clinched the Premier Academy League Group C title with a decisive win away to fellow hopefuls Everton.
Paul McGuinness' side needed just a point in United's final game of the season, while Everton had to beat United and Manchester City in their remaining two games. But it was Keane, Morrison and co. who came out on top.
Keane put United in front after 26 minutes in the first half with some fine footwork inside the area before a typically cool finish under pressure from a posse of blue shirts.
Then, in the 89th minute, Morrison made sure of the win to seal United's title triumph with a neat finish to wrap up all three points.
The win secures a place in the play-offs with the three other regional division winners to determine the destination of the overall Premier Academy League trophy.
The Reds have been drawn in a home semi-final tie against Arsenal, winners of Group A, for a chance to reach the final to decide the Premier Academy League winner outright.