United bid to win the FA Youth Cup for the 10th time when travelling to Bramall Lane for the first leg of the final against Sheffield United.
Tuesday night's match, which is live on MUTV, sees Paul McGuinness' side look to lift the trophy after disposing of the likes of Liverpool and Chelsea in previous rounds.
John Cofie has recovered from a knee injury that had kept him out since January, featuring for both the academy and reserve sides recently, and McGuinness is set to take a strong squad across the Pennines.
United's academy director Brian McClair told TheFA.com: "This club has a very proud heritage in this competition and it's a nice opportunity for everyone involved in the academy to celebrate at an event like this.
"The history of whether their club have played in an FA Youth Cup final before is irrelevant though, our group of players have never played in the final before either.
"At every level, the players and teams of this club prepare in the right way and any club who has reached the FA Youth Cup final deserves our respect.
"It is a very difficult road to get there and they have beaten some very good teams along the way.