The Reds breezed past Swansea in the fifth round with a 5-1 win at the Liberty Stadium, even without key players such as skipper Luke McCullough and midfielder Adnan Januzaj.
Jack Barmby has scored in every round so far so he'll be looking to start in the quarter-final after coming off the bench in Saturday's 3-3 league draw with Wolves. James Wilson and Kenji Gorre enhanced their prospects of being involved with their first goals of the season while Tyler Blackett and Mats Daehli could be reintroduced to the line-up.
"When the youth team played at Swansea, they had five players missing," Sir Alex Ferguson told MUTV recently. "Particularly in the case of Adnan, it was a big loss to them. Tom Lawrence and Luke McCullough too, there were quite a few of them out. But they still won the game 5-1 and it's a great boost to [coaches] Paul McGuinness and Jim Ryan."
Charlton earned the right to play at Old Trafford by beating Spurs with Oliver Muldoon's late free-kick . The Addicks are currently on a 10-match unbeaten run and even though key midfielder Bradley Jordan is ruled out with ankle ligament damage, coach Steve Avory believes his team will be ready for the challenge. "I am confident about it," Avory told Charlton's official website, "because I know my players can deal with the experience."