The youngsters will face Tatran Presov and Dukla Banska Bystrica in friendlies and a 28-man squad has provisionally been named for the trip. On last year's excursion, Gyliano van Velzen scored the only goal against Tatran while Jack Barmby hit a hat-trick in a 4-3 victory over Konoplyov Football Academy.
Summer recruits Sean Goss and Matthew Willock are among those in the party this year - as well as 11 players who were on the 2011 visit, including Mats Daehli, Adnan Januzaj and Kenji Gorre.
James Weir and Liam Grimshaw feature after playing their part in England Under-18s' 2-0 victory against Italy on Wednesday.
United squad: Joel Castro Pereira, Pierluigi Gollini, Kieran O'Hara; Ben Barber, Declan Dalley, Callum Evans, Liam Grimshaw, Nicholas Ioannou, Donald Love, Ryan McConnell, Louis Rowley, Matthew Wilkinson; Mats Daehli, Kenji Gorre, Sean Goss, Joshua Harrop, Andreas Pereira, Adnan Januzaj, Paddy McNair, Ben Pearson, Joe Rothwell, Jack Rudge, James Weir, Matthew Willock; Jack Barmby, Sam Byrne, Ashley Fletcher, James Wilson.