The Clarets knocked United out of the competition last year with a dramatic 4-3 extra-time triumph at Old Trafford and the opportunity to perform at Turf Moor is one to relish for Paul McGuinness' young hopefuls.
"I would imagine there will be a bit of a crowd in and to play at any league ground is great for them," explained McGuinness. "It is why the FA Youth Cup is so important. It provides the platform to play in that environment and, if you get towards the final, you usually play in front of big crowds. So it is a big boost to your experience and confidence if you do well."
Several of the players eligible for the competition have also appeared in Europe in the new UEFA Youth League which should stand them in good stead.
"It's all good experience for them," added McGuinness. "To get an idea of first-team football, playing against different teams and to have that big-match feel as part of the build-up to playing in the Youth Cup.
"It's better than just playing at a training ground every week as they have been in a stadium and there is a bit of transition there. This is an opportunity for them to have a run but you just cannot tell how far you are going to go. The more you get used to it, the confidence gets going and you get on a roll so it can be a springboard for people's careers. It really can help them if the manager sees them do well.
"If they get in the first team or anybody else's first team, they will have already played in front of say 25,000 or 30,000 in the FA Youth Cup and be more likely to be ready for it and much