Manchester United's FA Youth Cup tie at Huddersfield Town will take place on Friday 14 February.
The Reds' reward for defeating Leicester City after extra-time in the fourth round is a third consecutive match on the road against a Championship club.
United have not faced Huddersfield in senior competition since March 1972 and the Reds have never played at the John Smith's Stadium, formerly named the Alfred McAlpine and Galpharm Stadium.
Ex-Oldham striker Frankie Bunn is in charge of the Terriers' Academy team with former Red Mark Robins managing the first team. The Yorkshiremen won 4-2 at West Brom in the previous round and have posted a fine record in their division, the Professional Development League Two.
If the score is level at the end of 90 minutes, an additional half an hour of extra time will be played, plus penalties if required. The scheduled fixture at Everton on Saturday 15 February has now been postponed with a new date to be confirmed.