Giggs will make his 600th Premier League appearance if he is involved against Wigan, while Scholes and Ferdinand are one shy of 700 and 400 senior outings for the club respectively.
Sir Alex credits the players’ longevity to the way they have looked after themselves and believes Giggs is perfectly capable of playing into his 40s.
"My personal feeling is that Ryan can play for another couple of years," the Reds boss said.
"Paul's a different physical specimen to Ryan and he's had his injuries – two knee injuries, an eye injury – and yet he's playing his 700th game. It's phenomenal.
"Rio's also playing his 400th game. It's a landmark for the three players and it's a great example to the younger players about what can be achieved if they sacrifice in football. These players have done that or they would never have got to this stage."
Debut: 2 March 1991
Total appearances: 910
Premier League appearances: 599
Debut: 21 September 1994
Total appearances: 699
Premier League appearances: 485
Debut: 27 August 2002
Total appearances: 399
Premier League appearances: 271
"It's a landmark for the three players and it's a great example to the younger players about what can be achieved if they sacrifice in football."
– Sir Alex Ferguson