Eight changes for the Reds

Sergio Romero starts between the sticks for United in just his second senior appearance of the season, and his first in Europe since last year.

Ahead of the Argentinian keeper, Jose has made three changes to his back four, with Diogo Dalot, Chris Smalling and Ashley Young being replaced by Antonio Valencia, Eric Bailly and Marcos Rojo.

Former Valencia man Juan Mata is the only midfielder to keep his place from the victory at Fulham, with Marouane Fellaini, Andreas Pereira, Fred and Paul Pogba coming into the side.

Romelu Lukaku, who netted at Old Trafford at the weekend, starts up front for the Reds and will be hoping to add to his six goals in all competitions this season.

On the bench, it is a big night for youngsters James Garner and Mason Greenwood who could make their competitive debuts for the first-team in Spain on Wednesday after being named on the substitutes' bench, with Scott McTominay missing out.

Jose told BT Sport ahead of the game: "The majority of players playing (tonight) are ones without many minutes. They need to play and need to put themselves available for the team when the team needs them.

"It’s a great occasion in the Champions League to play. Romero, for example, is normally waiting for a cup match to play but now he has the chance to play in the Champions League. Pereira, the two kids on the bench too, it’s an opportunity for them.

"Paul [Pogba], Lukaku – people that we pick come to the team again to get their confidence levels back, like Lukaku did in the last match where played and scored at Old Trafford," he added.

United: Romero; Valencia (c), Jones, Bailly, Rojo; Fred, Fellaini Pogba Mata; Lukaku, A. Pereira.

Substitutes: Grant, Young, Garner, Herrera, Lingard, Greenwood, Rashford.