Manchester United forward Alexis Sanchez sustained a hamstring injury during a training session today (Thursday) and the problem will require further investigation to confirm its severity.
This news comes 12 hours before Jose Mourinho holds his pre-match press conference at the Aon Training Complex on Friday morning, as the Reds prepare to face Southampton away in Saturday tea-time's Premier League fixture.
The manager could then give further updates on his squad for the south-coast trip but it seems he will have to rule out Alexis, who appeared as a substitute in the recent league games against Manchester City and Crystal Palace and last started for United in the impressive 2-1 win over Juventus in the Champions League.
You can follow Mourinho's Friday-morning media briefing by downloading our official app. Key quotes and video clips will be available there from 10:30 GMT.