Darren Fletcher has been handed his first FA Youth Cup assignment as Manchester Under-18s coach, following the third-round draw on Friday.
The Reds are at home to Peterborough United, who beat Lincoln City and Boldmere St Michaels to reach this stage, with clubs from the Premier League and Championship now entering the competition.
Fletcher will be looking forward to taking charge of his team in the historic competition, with the tie scheduled to be played before 13 December.
Extra-time and penalties will be required to decide games after 90 minutes if the scores are level.
Fixture details will be relayed in due course, when available, including coverage of the tie.
The Under-18s' next scheduled outing, against Birmingham City, will be covered live by MUTV on Saturday 22 November.
The Reds have lifted the trophy more times than any other club (11) and reached the semi-finals in 2024/25, losing to eventual winners Aston Villa in a penalty shootout.
FA YOUTH CUP THIRD-ROUND DRAW
Oxford United v Wigan Athletic or Walsall
Needham Market or Southend United v Swindon Town or Dorking Wanderers
Newcastle United v Portsmouth
Crewe Alexandra or Halifax Town v Barnet or Colchester United
Barnsley or Mansfield Town v Arsenal
Rotherham United or Fleetwood Town v Blackpool or Aylestone Park
Bristol City v Leeds United
Sunderland v Nottingham Forest
Tottenham Hotspur v Brighton & Hove Albion
West Brom v Bournemouth
Millwall v Everton
Tranmere Rovers or Bolton Wanderers v Leicester City
Blackburn Rovers v Southampton
Manchester City v Fulham
Manchester United v Peterborough United
Coventry City v Birmingham City
Wrexham v Northampton Town or Port Vale
Reading v Middlesbrough
Queens Park Rangers v Oxford City or Walton & Hersham
Norwich City v Stoke City
Hull City v Swansea City
Crystal Palace v Bradford City or York City
Watford v Plymouth Argyle or Milton Keynes Dons
Tiverton Town or Cambridge United v Derby County
Wycombe Wanderers or Bromley v Sheffield Wednesday
Burnley v Wolverhampton Wanderers
Grimsby Town or Doncaster Rovers v Aston Villa
Sheffield United v Ipswich Town
Gillingham or Forest Green Rovers v Stevenage
Brentford v Chelsea
Preston North End v West Ham United
Liverpool v Charlton Athletic