Amad and Bryan Mbeumo both start for Manchester United against Bournemouth, ahead of their involvement at the Africa Cup of Nations later this month.
The duo are set to represent Ivory Coast and Cameroon respectively at the tournament, starting on Sunday, which made their availability a doubt for the 20:00 GMT kick-off.
Noussair Mazraoui has also been selected for the competition, by hosts Morocco, who play in the weekend's opening fixture. The defender isn't involved tonight, but it is a boost for Ruben Amorim to have two of his three imminently departing Reds at Old Trafford to face the Cherries.
Striker Benjamin Sesko, who has missed United's last four matches with an injury, is fit to return to the bench despite dealing with illness in the build-up to this one.
The boss makes just the one change to the side that started the 4-1 win away to Wolves last Monday, with Mazraoui replaced in the line-up by centre-back Leny Yoro.
Ayden Heaven looks set for his third successive Premier League start, while Luke Shaw continues his run of being in every one of our top-flight line-ups this season.
Mbeumo's involvement means he also maintains the same streak, a feat also achieved by captain Bruno Fernandes, who wears the armband again this evening.
Mason Mount, on the scoresheet alongside Fernandes and Mbeumo at Wolves last week, is another Red to keep his place in Amorim's XI.
Bournemouth, meanwhile, also make just the one alteration, with Tyler Adams returning from suspension to take the midfield place of Alex Scott.
THE TEAMS
United: Lammens; Yoro, Heaven, Shaw; Amad, Casemiro, Fernandes (c), Dalot; Mbeumo, Mount; Cunha.
Substitutes: Bayindir, Dorgu, Fredricson, Malacia, Martinez, Mainoo, Ugarte, Sesko, Zirkzee.
Bournemouth: Petrovic; Smith (c), Diakite, Senesi, Truffert; Tavernier, Adams; Jimenez, Kluivert, Semenyo; Evanilson.
Substitutes: Dennis, Araujo, Soler, Brooks, Scott, Adli, Kroupi, Hill, Unal.