Manchester United boss Ole Gunnar Solskjaer has made six changes for the visit of West Ham United in the Emirates FA Cup fifth round.
The Reds take on David Moyes's in-form Hammers with a place in the quarter-finals at stake.
After defeating Watford and Liverpool to get to this stage, United will hope to overcome the east Londoners at Old Trafford, with the action kicking off at 19:30 GMT.
Donny van de Beek is expected to feature in the no.10 role, in place of Bruno Fernandes, while Anthony Martial and Marcus Rashford both make their 250th appearance for the club.
Dean Henderson, Alex Telles and Nemanja Matic all start as Ole shuffles his pack, with new recruit Amad handed a spot on the bench following two excellent performances with the Under-23s. Lee Grant is the substitute keeper.
West Ham are without Michail Antonio but former United Under-18s striker Mipo Odubeko is among their substitutes.
“Amad has been bright since he's come in,”
Ole told MUTV's Stewart Gardner. “He did really well in the Reserves games and he's a player who can create things out of nothing. So he's there is we need something.
“We hope the front three are going to hit form. We've seen them last season, the three of them. This year, we've added Edinson [Cavani] so that's given more competition for places but it's good to see them together again, and good to see Donny too.”
THE TEAMS
United: Henderson; Wan-Bissaka, Lindelof, Maguire (c), Telles; Matic, Fred; Greenwood, van de Beek, Rashford; Martial.
Subs: Grant, Shaw, Tuanzebe, Williams, Amad, Fernandes, James, McTominay, Cavani.
West Ham: Fabianski; Coufal, Dawson, Ogbonna, Cresswell; Rice, Noble (c); Fornals, Soucek, Bowen; Yarmolenko.
Subs: Trott, Diop, Balbuena, Johnson, Fredericks, Alves, Lanzini, Benrahma, Odubeko.