Michael Carrick has named his Manchester United team for the 198th derby against City.
Our head coach oversees his first game since replacing interim boss Darren Fletcher at the helm, with a tough challenge sure to be posed by Pep Guardiola's Blues.
The 12:30 GMT kick-off at Old Trafford provides a first chance for Amad and Bryan Mbeumo to be part of a matchday squad in 2026, following their stint at the Africa Cup of Nations, in Morocco.
Both forwards start as two of five changes made to the XI on duty for the Emirates FA Cup third-round tie against Brighton & Hove Albion, last time out.
Mason Mount and Benjamin Sesko, with three goals in his last two matches, move to the substitutes' bench.
Harry Maguire is introduced into defence, making his first start since the draw at Tottenham Hotspur in November, while Casemiro is in for Manuel Ugarte, and partnering Kobbie Mainoo in midfield.
Luke Shaw, with a fine Manchester derby goal on his CV, is recalled after being rested last Sunday.
Shea Lacey, who scored both goals for the Under-21s in a 2-2 draw at Fulham on Friday, is suspended.
Noussair Mazraoui has the AFCON final against Senegal on his agenda this weekend, while Dutch duo Matthijs de Ligt and Joshua Zirkzee are not in the squad.
THE LINE-UPS
United: Lammens; Dalot, Maguire, Martinez, Shaw; Casemiro, Mainoo; Amad, Fernandes (c), Dorgu; Mbeumo.
Substitutes: Bayindir, Heaven, Malacia, Yoro, J. Fletcher, Mount, Ugarte, Cunha, Sesko.
City: Donnarumma; Lewis, Khusanov, Alleyne, Ake; Rodri; Semenyo, Foden, Bernardo Silva (c), Doku; Haaland.
Substitutes: Trafford, Bettinelli, Ait-Nouri, Mfuni, O’Reilly, McAidoo, Mukasa, Reijnders, Cherki.