Jose Mourinho has made six changes to the side to face Young Boys in the Champions League from the side who drew with Crystal Palace last Saturday.
Antonio Valencia is back as captain for his first start in the Reds XI since the European home match against Valencia at the beginning of October.
He replaces Matteo Darmian who played in the Palace stalemate. Also returning to the starting line up for the first time in two months is Phil Jones, who last started in the Carabao Cup game against Derby County at Old Trafford in September. Jones comes in for the injured Victor Lindelof, while Luke Shaw is back after suspension.
In midfield Marouane Fellaini, who came on as a sub in the 0-0 draw with Palace, starts alongside Nemanja Matic and Fred.
Marcus Rashford leads the line up front, supported by Jesse Lingard and Anthony Martial as the Reds look to seal early qualification for the Champions League knockout stages.
Speaking to BT Sport before the game, Mourinho explained his team changes, saying:
“They are always asking for Rashford to play, so you cannot complain that Rashford is playing as a number nine. And people like Fred, they play, so you cannot complain that Fred is playing. So fresh blood, fresh legs, people that did not play in the last match two days ago.
”I always think that to play after two days is never so easy. I try to keep a certain stability in the team, but with fresh people and the three attacking players are Lingard, Rashford and Martial. All of them young, all of them fast, all of them are supposedly fresh, so that's the way we go.
On the game, Jose added: ”The last performance at home was a frustrating game without goals and the objective tonight is to try and win against a team that is not easy. [They] only [have] one point, but good matches, good quality, very competitive even in the results against Valencia. I think they change the way they play. I think they're going to play much more defensive than they used to. So I think it is going to always be difficult.
United: De Gea, Valencia (c), Smalling, Jones, Shaw, Matic, Fellaini, Fred, Lingard, Rashford, Martial.
Subs: Romero, Bailly, Mata, McTominay, A.Pereira, Pogba, Lukaku.