Erik ten Hag has made two changes to his Manchester United starting line-up, for Saturday's visit to Southampton.
Amad and Christian Eriksen have been brought into the XI, in place of Alejandro Garnacho and Casemiro respectively.
The South American pair are on the substitutes' bench, alongside new signing Manuel Ugarte, who will make his United debut if introduced at St Mary's Stadium.
Ugarte signed for the Reds on deadline day and played twice for Uruguay during the recent World Cup qualifiers.
Fellow summer arrivals Noussair Mazraoui, Matthijs De Ligt and Joshua Zirkzee retain their place in the team after the international break.
Eriksen makes his first start of the new campaign, while Amad will be aiming to show the form that enabled him to claim our August Player of the Month award.
United: Onana; Mazraoui, De Ligt, Martinez, Dalot; Mainoo, Eriksen; Amad, Fernandes (c), Rashford; Zirkzee.
Substitutes: Bayindir, Evans, Maguire, Casemiro, Collyer, Ugarte, Antony, Garnacho, Wheatley.
Southampton: Ramsdale; Sugawara, Stephens (c), Bednarek, Walker-Peters; Downes, Ugochukwu, Fernandes, Dibling; Archer, Brereton Diaz.
Substitutes: McCarthy, Harwood-Bellis, Taylor, Fraser, Lallana, Aribo, Cornet, Armstrong, Stewart.